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Baxalta has a well-established hematology portfolio, which includes Adynovate antihemophilic factor recombinant , PEGylated, an extended circulating half-life recombinant factor VIII rFVIII treatment for hemophilia A which is approved in the US and is focused on introducing new treatments for hemophilia and other rare chronic bleeding disorders. Baxalta is also contributing a portfolio of immunoglobulin IG products, most notably the recently launched Hyqvia, a subcutaneous IG treatment for patients with primary immunodeficiency, as well as a pipeline of products.
In neuroscience, Shire has a focus on treatments for attention deficit hyperactivity disorder ADHD , which includes a new indication for Vyvanse lisdexamfetamine dimesylate for adults with moderate-to-severe binge eating disorder. Shire is focused on building its franchise ophthalmology with the projected launch of Lifitegrast, contingent upon regulatory approval, for dry eye disease; SHP for infectious conjunctivitis entering Phase III trials in , and SHP for the treatment of retinopathy of prematurity, generating results from its Phase III trials which are expected in The company will create a biologics manufacturing campus, which it expects will lead to the creation of approximately permanent jobs on a acre site at Piercetown, County Meath.
Construction of the new site will begin in mid with the site expected to be operational by mid The Cambridge site also includes warehouse facilities. The Lexington site also includes laboratories, warehousing, and distribution operations. The company also has a warehousing and distribution facility in Florence, Kentucky, a warehousing facility in North Reading, Massachusetts, and laboratory and office space in Sao Paulo, Brazil.
Baxalta, which was spun off from Baxter as a stand-alone biopharmaceutical company in , has enhanced its product positions through targeted acquisitions and collaborations. In March , Baxalta acquired SuppreMol GmbH, a biopharmaceutical company based in Germany with an early-stage development portfolio of treatment options for autoimmune and allergic diseases, focusing on the modulation of Fc receptor signaling pathways, an immune target that could have broad applications in autoimmune disorders.
In April , Baxalta acquired Chatham Therapeutics, gaining broad access and intellectual property rights to its gene-therapy platform for the treatment of hemophilia B BAX , currently in Phase I clinic trials as well as a preclinical hemophilia A program, and the potential future application to additional hemophilia treatments.
Baxalta also has several pacts in biosimiars. It has a collaboration with Coherus BioSciences, Inc. On the innovator side. Baxalta has exclusive commercialization rights for all indications outside the United States, and will jointly commercialize pacritinib in the United States with CTI BioPharma. In , Baxalta acquired the investigational hemophilia compound and related assets from Inspiration BioPharmaceuticals, Inc.
Inspiration , as well as certain other assets, including manufacturing operations, from Ipsen Pharma S. Another pact involves Hyqvia, a product consisting of human normal immunoglobulin IG and recombinant human hyaluronidase licensed from Halozyme Therapeutics, Inc. Hyqvia was approved in Europe in for adults with PID syndromes and myeloma or chronic lymphocytic leukemia CLL with severe secondary hypogammaglobulinemia and recurrent infections, and also in the United States in for adults with PID.
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Prescribing practices are as unique as patient populations, and pharmacies have varying levels of nutrition compounding capability and expertise. Baxter's leading Parenteral Nutrition Portfolio . Jan 8, · OSAKA, JAPAN, January 8, – Takeda Pharmaceutical Company Limited (TSE/NYSE:TAK) (“Takeda”) today announced the completion of its acquisition of Shire . Jun 3, · Shire said today it has completed its $32 billion merger with Baxalta, creating what it called the global market leader in rare diseases and other specialized disorders.