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Kristina Forslind. Prediction of radiographic progression RP in early rheumatoid arthritis eRA would be very useful for optimal choice among available therapies. RP was defined as an increase in the Van der Heijde-modified Sharp score by more than five points over 1 year.

Associations between baseline disease activity measures, the MBDA score, and 1-year RP were evaluated using univariate and multivariate logistic regression, adjusted for potential confounders.

None of the former and only one of the l Agata Burska. Daniel Perez-Witzke. This may result in an attractive approach for the treatment of both T-cell driven autoimmune diseases and T-ALL. Affimer binding to IL-7Ra was confirmed by pull-down assays soluble and Flow cytometry membrane. Our work demonstrates the possibility of screening an Affimer library for a cytokine-receptor target, and selecting specific binders, some of which showed the desired antagonist activity of the cytokine signalling cascade.

IL-7 itself is a validated target, so this work offers an alternative to antibody-mediated protein interference. The 18th annual international Targeted Therapies meeting brought together over leading scientists and clinicians from around the world in the field of rheumatology. During the meeting, breakout sessions were held consisting of 5 disease-specific groups each with experts assigned to each group based on clinical or scientific expertise. Needs were prioritised as primary or secondary.

Overall, similar primary unmet needs were identified within each disease foci. Within translational science, these included the need for better understanding the heterogeneity within each disease, such tha Gesellschaft fuer klinische Forschung e.

Society for Clinical Research. Grachtenhaus-Apotheke, Inh. Klaus Stegemann e. Groupe Hospitalier Paris Saint-Joseph. Hamilton Health Sciences Corporation. Helix Product Development Ireland Limited. Helsingin ja uudenmaan sairaanhoitopiiri.

Hospital for Children and Adolescents. Indevus Pharmaceuticals Incorporated. Institut fuer Gesundheits- und Praxismanagement GmbH. Institute for Biomedical Aging Research. Institute of Hematology and Blood Transfusion. International Centre for Therapeutic Research for Spain. Investigator Trondheim Hudlegesenter AS. Iterum Therapeutics International Limited. Jagiellonian University Medical College. Kurort Forschungsverein Bad Steben e.

Landesklinikum Thermenregion Hochegg. Leeds Teaching Hospitals and University of Leeds. Lithuanian University of Health Sciences. Macarthys Laboratories Limited trading as Martindale Pharma. Mater Misericordiae University Hospital. Medical Centre of Postgraduate Education.

Medical Developments International Limited. Medical Research Institute of New Zealand. Molecular Insight Pharmaceuticals, Inc. National University of ireland Galway. Netherlands Immunotherapy Working Group for Oncology. Northern Health and Social Care Trust.

Oncology Institute of Southern Switzerland. Orthopaedic Syrgery Unit Northern Jytland. Research Institute of Biological Psychiatry Sct. Research Maatschap Cardiologen Rijnmond Zuid. River Vision Development Corporation. Robert Bosch Society for Medical Research. Sheffield Health and Social Research Consortium.

Anne's University Hospital Brno. Stanmore Clinical Research Facility Ltd. Stichting Rotterdams Onderzoeksconsortium Kindergeneeskunde. Swedish Institute for Infectious Disease Control. Tetherex Pharmaceuticals Corporation. The Hospital District of Southwest Finland. Unclear Sponsor Name Given - Allergiklinikken.

Unclear Sponsor Name Given - Departmnet of nephrology. Unclear Sponsor Name Given - Dept anaesthesiology and intensive care. Unclear Sponsor Name Given - Dept. Unclear Sponsor Name Given - Dpt. Unclear Sponsor Name Given - Endokrinologisk afd. Unclear Sponsor Name Given - Fertilitetsklinikken. Unclear Sponsor Name Given - Klinik f. Innere Med. Internal Medicine, Div. Unclear Sponsor Name Given - Medicinsk afdeling. Unclear Sponsor Name Given - Radiopharmacy.

Klinik f. Unclear Sponsor Name Given - Society institute for clinical research. Unclear Sponsor Name Given - Univ. Unclear Sponsor Name Given - U. University of Texas Health Science Center. Verein fuer Krebsfoschung Society for Cancer Research.

West-ward Pharmaceutical Corporation. Alexander IV sp. Partnership Ortopedika Surgery Specialistic Center. Ambulance Service, Stockholm City Council. AO Garibaldi, S. Luigi Curro, Ascoli Tomaselli. AO Istituti Clinici de Perfezionamento. AOU S. Maria della Misericordia de Udine.

Associazione Italiana Endocrinologia-Metabolismo-Ipofisi. Associazione Italiana per lo Studio del Dolore. Associazione Italiana Pneumologi Ospedalieri. Associazione Piemontese di Oncologia Toracica. Associazione Salentina Angela Serra Onlus. Associazione S. Azienda Ospedaliera Bianchi-Melacrino-Morelli. Azienda Ospedaliera Ospedale di Circolo A. Di Rilievo Regionale. Maria di Terni. Azienda Ospedaliera San Camillo Forlanini. Azienda Sanitaria Locale 4 di Torino. Azienda Sanitaria Locale 9 di Grosseto.

Azienda Sanitaria Locale Bi di Biella. Belgian Study Group for Pediatric Endocrinology. Beth Israel Deaconess Medical Center. Biocruces Bizkaia Health Research Institute. Blood Transfusion Centre of Slovenia. Cardioangiologisches Centrum Bethanien. Centre of Thrombosis and Haemostasis. Centro di Riferimento Oncologico di Aviano. Centro di Riferimento Oncologico di Basilicata.

Centro per la Prevenzione e Cura del Tabagismo. Children's Cancer and Leukaemia Group. Children's Hospital of Eastern Ontario. Children's Memorial Health Institute. Cholnoky F. Christelijke Vereniging voor de Verpleging van Lijders aan Epilepsie. Cincinnati Children's Hospital Medical Center. Complejo Hospitalario Universitario de Albacete. Complexo Hospitalario Universitario de Pontevedra. Conrad Eastern Virignia Medical School. Consortium for Biological and Pharmacological Evaluations.

Consorzio per Valutazioni Biologiche e Farmacologiche. Directorate of Defence Rehabilitation. Dizal Jiangsu Pharmaceutical Co. Lola Ledesma. Eastern Norway Regional Health Authority. European Society for Blood and Marrow Transplantation. Federal Ministry of Education and Research. Finnish Institute for Health and Welfare. Fondation Ophtalmologique Adolphe de Rothschild. Fondazione del Piemonte Per L'Oncologia. Fondazione dell'Istituto Toscano Tumori. Fondazione Istituto Neurologico Nazionale C.

Fondazione Istituto San Raffaele-G. Fondazione per la Medicina Personalizzata. Fondazione Ricerca Trapianto di Midollo Osseo. Fondazione Toscana Gabriele Monasterio. Forschergruppe Diabetes e. Forschungsinstitut der Diabetes-Akademie Bad Mergentheim e. Fundacion de Investigacion en Red en Enfermedades. Fundation of Experimental and Clinical Oncology.

GeneCare Research Institute Co. General University Hospital in Prague. German Foundation for Chronically Ill. Global Coalition for Adaptive Research. Greek Corporation of Invasive Cardiology. Grupo Oncopaz y Hospitales Asociados. Hellenic Cardiovascular Research Society. Hellenic Society for the Study of Bone Metabolism. Hellenic Society of Medical Education.

Helse More og Romsdal Hospital Trust. Hersenstichting Netherlands Brain Foundation. Hospital Arnau de Vilanova de Lliria. Hospital Arnau de Vilanova de Valencia. Hospital District of Southwest Finland. Hospital General Universitario de Alicante. Hospital Regional Universitario. Hospital Universitari Arnau de Vilanova de Lleida. Hospital Universitari Sant Joan de Reus. Hospital Universitario 12 de Octubre. Hospital Universitario Central de Asturias. Hospital Universitario de Fuenlabrada.

Hospital Universitario Infanta Cristina. Hospital Universitario Puerta de Hierro. Hospital Universitario Virgen de las Nieves.

Hospital Universitario Virgen de Victoria.

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Alcon Pte Ltd, a subsidiary of Novartis AG at the time of the misconduct, separately entered into a deferred prosecution agreement in connection with a criminal information filed today in the District of New Jersey charging Alcon Pte Ltd with conspiracy to violate the books and records provision of the FCPA. Attorney Carpenito said.

We will protect our citizens, our economy, our way of life, and bring to justice anyone who breaks the law. Between and , Novartis Greece conspired with others to violate the FCPA by engaging in a scheme to bribe employees of state-owned and state-controlled hospitals and clinics in Greece in order to increase the sale of Novartis-branded pharmaceutical products.

Novartis Greece paid for those employees to travel to international medical congresses, including events held in the United States, as a means to bribe these officials in exchange for increasing the number of prescriptions they wrote for Lucentis, a prescription drug that Novartis Greece sold.

Novartis Greece employees traveled to the United States facilitated the provision of the improper benefits to publicly employed Greek health care providers. Novartis Greece also admitted that between and , Novartis Greece made improper payments to health care providers in connection with an epidemiological study that was intended to increase sales of certain Novartis-branded prescription drugs.

The epidemiological study was used as a vehicle to make improper payments to the health care providers in order to increase sales of certain Novartis-branded prescription drugs, and Novartis Greece employees recognized that many participating health care providers believed that they were being paid in exchange for writing prescriptions of Novartis products and not for providing data as part of a clinical study.

From through , Alcon Pte Ltd knowingly and willfully conspired with others to cause Novartis AG to maintain false books, records and accounts, as a result of a scheme to bribe employees of state-owned and state-controlled hospitals and clinics in Vietnam.

The false books and records resulted from a scheme in which Alcon Pte Ltd made corrupt payments through a third-party distributor to employees of state-owned and state-controlled hospitals and clinics in Vietnam in order to increase sales of intraocular lenses. Intraocular lenses are artificial replacement lenses that are implanted in the eye as part of a treatment for a variety of ailments, such as cataracts. Alcon employees in Vietnam, with the approval of executives and employees of Alcon Pte Ltd, reimbursed the distributor for up to 50 percent of the cost of the corrupt payments, and these reimbursements were falsely recorded as, among other things, consulting expenses, marketing expenses, and human resource expenses.

As part of the agreement, Novartis Greece agreed to continue to cooperate with the government in any ongoing or future criminal investigations concerning Novartis Greece, its executives, employees, or agents.

Novartis Greece and its parent company, Novartis AG, agreed to enhance their compliance programs and to report to the government on the implementation of their enhanced compliance programs. Alcon Pte Ltd agreed to continue to cooperate with the government in any ongoing or future criminal investigations concerning Alcon Pte Ltd, its executives, employees, or agents.

Alcon Pte Ltd and its parent company, Alcon Inc. The companies also engaged in remedial measures, including terminating and disciplining individuals who orchestrated the misconduct, adopting heightened controls and anti-corruption protocols, and significantly increasing the resources devoted to compliance. The settlements with Novartis represent the second time the drugmaker has been fined for alleged foreign bribery-related offenses. The Novartis and Alcon subsidiaries involved in the misconduct entered into deferred prosecution agreements with the Justice Department to resolve the criminal charges, which were filed in the U.

District Court in New Jersey. The latest investigations into Novartis by U. Greek prosecutors in sent a report to parliament alleging that Novartis employees had paid tens of millions of euros in bribes to doctors and politicians to fix the price of its drugs at artificially high prices. Novartis has long denied some of those claims. Alcon, which merged with Novartis in and was spun off from the firm last year, said it was pleased to resolve the investigations. The agreements announced Thursday detailed a scheme by the Novartis subsidiary, based in Greece, to bribe employees of Greek state-owned and state-controlled hospitals and clinics by sponsoring their travel to international medical conferences, including events held in the U.

What the subsidiary wanted in return was clear, prosecutors said. According to the agreement, the Novartis unit expected the publicly employed health-care workers to increase the number of prescriptions they wrote for Lucentis, a medication used to treat certain eye conditions. No presents anymore. The Novartis subsidiary also admitted in its settlement with prosecutors to paying bribes between and to health-care providers in connection with an epidemiological study aimed at increasing the sales of Novartis-branded drugs.

The bribery schemes constituted a conspiracy to violate the FCPA, according to prosecutors. In attempting to hide the schemes, the Greek subsidiary also caused Novartis to record false books and records, in what constituted a second conspiracy to violate the antibribery statute, prosecutors said.

The Alcon subsidiary, meanwhile, also conspired to violate the FCPA by creating false books and records to hide alleged bribery schemes and other misconduct, according to the Justice Department and the SEC. The false books and records resulted in part from a scheme that took place between to in which Alcon employees in Vietnam paid bribes through a third-party distributor to employees of state-owned and state-controlled hospitals and clinics in the southeast Asian country, prosecutors said.

The scheme was intended to increase the sale of artificial lenses used to treat cataracts and other ailments. Both companies have agreed to enhance their compliance programs and file reports on their efforts, authorities said.